All Publications from the SPP1926

2020

A Müller-Deku, J Meiring, K Loy, Y Kraus, C Heise, R Bingham, K Jansen, X Qu, F Bartolini, L Kapitein, A Akhmanova, J Ahlfeld, D Trauner*, O Thorn-Seshold*; Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton. Nature Communications 2020, 11, 4640.

Vierock J, Rodriguez-Rozada S, Pieper F, Dieter A, Bergs A, Zeitzschel N, Ahlbeck J, Sauter K, Gottschalk A, Engel AK, Hegemann P, Wiegert S. (2020) BIPOLES: a tool for bidirectional dual-color optogenetic control of neurons. bioRxiv, 16th July 2020. doi: 10.1101/2020.07.15.204347.

2019

Azimi Hashemi N*, Bergs ACF*, Schüler C, Scheiwe AR, Steuer Costa W, Bach M, Liewald JF, Gottschalk A. (2019) Rhodopsin-based voltage imaging tools for use in muscles and neurons of Caenorhabditis elegans. PNAS 116: 17051-60. doi: 10.1073/pnas.1902443116.

Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. (2019) A photoactivatable botulinum toxin for inducible control of neurotransmission. Neuron 101: 863-875. doi: 10.1016/j.neuron.2019.01.002.

Makowka,P., Bruegmann, T., Dusend, V., Malan, D. ,Beiert, T., Hesse, M., Fleischmann, B.K., Sasse, P. Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision. (2019). Nature Communications 10: 1281.

Woldemariam S, Nagpal J, Hill T, Li J, Schneider M, Shankar R, Futey M, Varshney A, Ali N, Mitchell J, Andersen K, Barsi-Rhyne B, Tran A, Steuer Costa W, Krzyzanowski M, Yu Y, Brueggemann C, Hamilton S, Ferkey D, VanHoven M, Sengupta P, Gottschalk A, L'Etoile N. (2019) Robust and sensitive GFP-based cGMP sensor for real time imaging in intact Caenorhabditis elegans. Genetics 213: 59-77. doi: 10.1534/genetics.119.302392.

2018

Alberio, L., Kukovetz, K. Thiel, G, Moroni, A (2018). A light-gated K+ channel for sustained neuronal inhibition in freely moving animals. Nat Methods 15: 969-976

Baaske J, Gonschorek P, Engesser R, Dominguez-Monedero A, Raute K, Fischbach P, Müller K, Cachat E, Schamel WWA, Minguet S, Davies JA, Timmer J, Weber W, Zurbriggen MD Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells. (2018). Sci Rep 8: 15024. DOI: 10.1038/s41598-018-32929-7

Balbach M, Beckert V, Hansen JN, Wachten D. Shedding light on the role of cAMP in mammalian sperm physiology. (2018). Mol Cell Endocrinol 468: 111-120

Bergs ACF, Schultheis C, Fischer E, Tsunoda SP, Erbguth K, Husson SJ, Govorunova E, Spudich JL, Nagel G, Gottschalk A, Liewald JF. (2018) Rhodopsin optogenetic toolbox v2.0 for light-sensitive excitation and inhibition in Caenorhabditis elegans. PLoS ONE 13(2): e0191802. doi: 10.1371/journal.pone.0191802

Bernal Sierra YA*, Rost BR*, Pofahl M*, Fernandes AM, Kopton RA, Moser S, Holtkamp D, Masala N, Beed P, Tukker JJ, Oldani S, Bönigk W, Kohl P, Baier H, Schneider-Warme F, Hegemann P, Beck H, Seifert R, Schmitz D (2018). Potassium channel-based optogenetic silencing. Nat Commun 9: 4611. doi: 10.1038/s41467-018-07038-8. (*co-first authors)

Brown J, Behnam R, Coddington L, Tervo DGR, Martin K, Proskurin M, Kuleshova E, Park J, Phillips J, Bergs ACF, Gottschalk A, Dudman JT, Karpova AY. (2018) Expanding the Optogenetics Toolkit by Topological Inversion of Rhodopsins. Cell 175: 1131-1140. doi: 10.1016/j.cell.2018.09.026

Chatelle C, Ochoa-Fernandez R, Engesser R, Schneider N, Beyer HM, Jones A, Timmer J, Zurbriggen MD*, Weber W*  A green light-responsive system for the control of transgene expression in mammalian and plant cells. (2018). ACS Synth Biol 7: 1349-1358. DOI: 10.1021/acssynbio.7b00450

Di Ventura B, Mootz HD. Switchable inteins for conditional protein splicing. (2018) Biol Chem. doi: 10.1515/hsz-2018-0309.

Falk T, Mai D, Bensch R, Cicek Ö, Abdulkadir A, Marrakchi Y, Böhm A, Deubner J, Jäckel Z, Seiwald K, Dovzhenko A, Tietz O, Dal Bosco C, Walsh S, Saltukoglu D, Tay T, Prinz M, Palme K, Simons M, Diester I, Brox T, Ronneberger O (2018). Deep Learning for Cell Counting, Detection, and Morphometry. Nat Methods, accepted.

Fosrster D, Kramer A, Baier H, Kubo F. Optogenetic precision toolkit to reveal form, function and connectivity of single neurons. (2018). Methods 150: 42-48.

Grimm C, Silapetere A, Vogt A, Bernal Sierra YA, Hegemann P Electrical properties, substrate specificity and optogenetic potential of the engineered light-driven sodium pump eKR2. (2018). Sci Rep 8: 9316. doi: 10.1038/s41598-018-27690-w.

Helassa N, Durst CD, Coates C, Kerruth S, Arif U, Schulze C, Wiegert JS, Geeves M, Oertner TG, Torok K (2018). Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses. PNAS 115: 5594.

Lutz AP, Schladebeck S, Renicke C, Spadaccini R, Mösch HU, Taxis C. Proteasome Activity Is Influenced by the HECT_2 Protein Ipa1 in Budding Yeast. (2018). Genetics. 209: 157-171. doi: 10.1534/genetics.118.300744.

Mark MD, Donner M, Eickelbeck D, Stepien J, Nowrousian M, Kück U, Paris F, Hellinger J, Herlitze S Visual tuning in the flashlight fish Anomalops katoptron to detect blue, bioluminescent light. (2018). PLoS One 13: e0198765

Nagpal J, Herget U, Choi MK, Ryu S. Anatomy, development, and plasticity of the neurosecretory hypothalamus in zebrafish. (2018). Cell Tissue Res. doi: 10.1007/s00441-018-2900-4.

Oda K, Vierock J, Oishi S, Rodriguez-Rozada S, Taniguchi R, Yamashita K, Wiegert JS, Nishizawa T*, Hegemann P*, Nureki O* (2018). Crystal structure of the red light-activated channelrhodopsin Chrimson. Nat Commun 9: 3949 (*corresponding authors)

Schneider-Warme F  The power of optogenetics: Potential in cardiac experimental and clinical electrophysiology. (2018). Herzschrittmacher-ther Elektrophysiol 29: 24-29.

Schneider-Warme F, Johnston CM, Kohl P  Organotypic myocardial slices as model system to study heterocellular interactions. (2018). Cardiovasc Res 114: 3-6

Schneider-Warme F, Ravens. Using light to fight atrial fibrillation. (2018). Cardiovasc Res 114: 635–637.

Stumpf A, Parthier D, Sammons RP, Stempel AV, Breustedt J, Rost BR, Schmitz D. Cannabinoid type 2 receptors mediate a cell type-specific self-inhibition in cortical neurons. (2018). Neuropharmacol 139: 217-225. doi: 10.1016/j.neuropharm.2018.07.020.

Wiegert JS, Pulin M, Gee CE, Oertner TG (2018). The fate of hippocampal synapses depends on the sequence of plasticity-inducing events. eLife 7: e39151

Wozny C, Beed P, Nitzan N, Pössnecker Y, Rost BR, Schmitz D VGLUT2 Functions as a Differential Marker for Hippocampal Output Neurons. (2018). Front Cell Neurosci 12: 337. doi: 10.3389/fncel.2018.00337.

2017

Berger TK, Fusshöller DM, Goodwin N, Bönigk W, Müller A, Dokani Khesroshahi N, Brenker C, Wachten D, Krause E, Kaupp UB, Strünker T  Post-translational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating. (2017) J Physiol 595: 1533-46

Bitzenhofer SH, Ahlbeck J, Wolff A, Wiegert JS, Gee CE, Oertner TG, Hanganu-Opatz IL (2017). Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks. Nat Commun 8:14563.

Fischer E, Gottschalk A, Schueler C (2017) An optogenetic arrhythmia model to study catecholaminergic polymorphic ventricular tachycardia mutations. Sci. Rep. 7: 17514. DOI:10.1038/s41598-017-17819-8

Hardung S, Alyahyay M, Eriksson D, Diester I. A Toolbox for Optophysiological Experiments in Freely Moving Rats. (2017) Front Syst Neurosci, 11: 27. doi: 10.3389/fnsys.2017.00027.

Hardung S, Epple R, Jackel Z, Eriksson D, Uran C, Senn V, Gibor L, Yizhar O, Diester I (2017). A Functional Gradient in the Rodent Prefrontal Cortex Supports Behavioral Inhibition. Curr Biol 27: 549-55.

Hasegawa E, Maejima T, Yoshida T, Masseck O, Herlitze S, Yoshioka M, Sakurai T, Mieda M (2017). Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity. PNAS 114: E3526-E3535

Hu C, Petersen M, Hoyer N, Spitzweck B, Tenedini F, Wang D, Gruschka A, Burchardt LS, Szpotowicz E, Schweizer M, Guntur AR, Yang C-H, Soba P (2017). Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior Nat Neuroscience 20: 1085–1095.

Jansen V, Jikeli JF, Wachten D. How to control cyclic nucleotide signaling by light. (2017) Curr Opin Biotechnol 48: 15-20.

Johnston CM, Rog-Zielinska EA, Wülfers EM, Houwaart T, Siedlecka U, Naumann A, Nitschke R, Knöpfel T, Kohl P, Schneider-Warme F  Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility. (2017). Prog Biophys Mol Biol 130(Pt B): 140-149

Rost BR, Schneider-Warme F, Schmitz D, Hegemann P (2017). Optogenetic Tools for Subcellular Applications in Neuroscience. Neuron 96: 572-603. doi: 10.1016/j.neuron.2017.09.047.

Soya S, Takahashi T, McHugh T, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T (2017). Orexin modulates behavioral fear expression through the locus coeruleus. Nat Commun 8: 1606

Wachten D, Jikeli JF, Kaupp UB. Sperm Sensory Signaling. (2017) Cold Spring Harb Pers-pect Biol 9: a028225. doi: 10.1101/cshperspect.a028225.

Wiegert JS, Mahn M, Prigge M, Printz Y, Yizhar O (2017). Silencing Neurons: Tools, Applications, and Experimental Constraints. Neuron 95: 504-529.

Wietek J, Rodriguez-Rozada S, Tutas J, Tenedini F, Grimm C, Oertner TG, Soba P, Hegemann P, Wiegert JS (2017). Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior. Sci Rep. 7: 14957. doi: 10.1038/s41598-017-14330-y.

2016

Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D (2016). A novel biosensor to study cAMP dynamics in cilia and flagella. eLife 5: e14052. doi: 10.7554/eLife.14052

Spoida K, Eickelbeck D, Karapinar R, Eckhardt T, Mark MD, Jancke D, Ehinger B, König P, Dalkara D, Herlitze S, Masseck OA (2016). Melanopsin Variants as Intrinsic Optogenetic On and Off Switches for Transient versus Sustained Activation of G Protein Pathways. Curr Biol 26: 1206-12.